Endocrine Abstracts

Background: Oxytocin is a nonapeptide hormone synthesized in the supraoptic and paraventricular nuclei of the hypothalamus. Oxytocin has an effect on uterine smooth muscle contraction, blood pressure, memory, learning capability, nursing, sexual and feeding behavior. Oxytocin and vasopressin stimulate the release of insulin and glucagon from the rat pancreas. Multi organelle effects of oxytocin make it as important hormone in body.Objective: The aim of t...

Introduction: Adrenal lesions occur in more than 10% of the general population. Most are benign, but 2.5% are metastatic disease to the adrenal from tumors such melanoma, renal, breast, colon and lung carcinoma. Adrenal metastatic disease is usually asymptomatic and diagnosed in the extension study or the primary tumor. However it is unusual as a presentation of an endocrine tumor or like the first manifestation of metastatic disease.We present two patie...

Introduction: Maturity-onset diabetes of the young (MODY) is a genetically, metabolically and clinically heterogeneous subtype of diabetes mellitus characterized by an early onset, an autosomal dominant inheritance, and a primary defect in insulin secretion. They are caused by mutations in a reduced number of β-cell genes. Mutations in glucokinase gen (MODY 2) and hepatic nuclear factor 1α (HNF 1α) (MODY 3) are the most common.Materials an...